Akr7a2 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comAkr7a2 Polyclonal Antibody for Mouse(Mus musculus)

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Akr7a2 (Gene name),

Aflatoxin B1 aldehyde reductase member 2 (Protein name ), ARK72_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Akr7a2(Afar;Akr7a5);

Protein name:

Aflatoxin B1 aldehyde reductase member 2;

Alternative:

Succinic semialdehyde reductase(SSA reductase);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer.

Function:

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Subcellular Location:

Golgi apparatus Cytoplasm

Protein Attributes:

Sequence length:

367

Sequence:

50:

100:

150:

200:

250:

300:

350:

367:

FDQAWNMVAH | ECPNYFR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:110198

SMR:

Q8CG76

String:

Q8CG76

Pfam:

PF00248

UniGene:

Mm.482154

Uniprot:

Q8CG76

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ELISA Kit for Mouse Aflatoxin B1 aldehyde reductase member 2

Cat.:

E15236h

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96T

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ELISA Kit for Mouse Aflatoxin B1 aldehyde reductase member 2

Cat.:

E15236m

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96T

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ELISA Kit for Mouse Aflatoxin B1 aldehyde reductase member 2

Cat.:

E15236r

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96T

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CLIA Kit for Mouse Aflatoxin B1 aldehyde reductase member 2

Cat.:

U15236r

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96T

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CLIA Kit for Mouse Aflatoxin B1 aldehyde reductase member 2

Cat.:

U15236m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse Aflatoxin B1 aldehyde reductase member 2

Cat.:

U15236h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Mouse Aflatoxin B1 aldehyde reductase member 2

Cat.:

P15236Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Aflatoxin B1 aldehyde reductase member 2

Cat.:

P15236Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Aflatoxin B1 aldehyde reductase member 2

Cat.:

P15236Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Aflatoxin B1 aldehyde reductase member 2

Protein for Mouse Aflatoxin B1 aldehyde reductase member 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Eye.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-367
strain: FVB/N.
tissue: Liver.
4.

"Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells."
Praml C. , Savelyeva L. , Schwab M.
Oncogene22:4765-4773(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-367
strain: BALB/c.
5.

"Characterisation of a novel mouse liver aldo-keto reductase AKR7A5."
Hinshelwood A. , McGarvie G. , Ellis E.
FEBS Lett.523:213-218(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-367;TISSUE SPECIFICITY
strain: CD-1.
tissue: Liver.
6.

Ellis E.M. , Hinshelwood A. , McGarvie G.
Submitted (2004-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 127 AND 162
7.

"Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins."
Kelly V.P. , Sherratt P.J. , Crouch D.H. , Hayes J.D.
Biochem. J.366:847-861(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GENE STRUCTURE
8.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
9.

"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-244;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
10.

"Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
Rardin M.J. , Newman J.C. , Held J.M. , Cusack M.P. , Sorensen D.J. , Li B. , Schilling B. , Mooney S.D. , Kahn C.R. , Verdin E. , Gibson B.W.
Proc. Natl. Acad. Sci. U.S.A.110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-136;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
11.

"Crystal structure of mouse succinic semialdehyde reductase AKR7A5: structural basis for substrate specificity."
Zhu X. , Lapthorn A.J. , Ellis E.M.
Biochemistry45:1562-1570(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 30-367 IN COMPLEX WITH NADP AND THE INHIBITOR TARTRATE;ENZYME REGULATION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;FUNCTION;SUBUNIT

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